Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels
نویسندگان
چکیده
منابع مشابه
Organic cation transporter 3 modulates murine basophil functions by controlling intracellular histamine levels
In this study, we identify the bidirectional organic cation transporter 3 (OCT3/Slc22a3) as the molecule responsible for histamine uptake by murine basophils. We demonstrate that OCT3 participates in the control of basophil functions because exogenous histamine can inhibit its own synthesis--and that of interleukin (IL)-4, IL-6, and IL-13--through this means of transport. Furthermore, ligands o...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2005
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20050195